Organic chemistry is the study of the synthesis, structure, reactivity and properties of diverse groups of chemical compounds primarily constructed of carbon. It has a wide application in pharmaceuticals, and it continues to be one of the drivers in the drug discovery process. Total synthesis may be accomplished either via a linear or convergent approach. In a linear synthesis—often adequate for simple structures—several steps are performed one after another until the molecule is complete. The chemical compounds made in each step are called synthetic intermediates. Most often, each step in a synthesis refers to a separate reaction taking place to modify the starting compound. For more complex molecules, a convergent synthetic approach may be preferable, one that involves individual preparation of several “pieces” (key intermediates), which are then combined to form the desired product. The need for high purity compounds in drug discovery continues to expand as higher throughput purification technique encourage better ways to discover new drugs and other materials. Flash and prep HPLC are the most accepted chromatography techniques that can produce high purity compounds with the aid of different detection techniques like UV and ELSD (Evaporative Light Scattering Detection). BUCHI has always been in the forefront in providing solutions for new drug development. Below are some of the examples of highly interesting publications using BUCHI Flash/ prep HPLC equipment for the purification of organic synthesised molecules and impurities.
Synthesis and Evaluation of 2-Aminothiophene Derivatives as Staphylococcus aureus Effux Pump Inhibitors
Tunable Approach for the Stereoselective Synthesis of 1-CDiethylphosphono (di_uoromethyl) Iminosugars as Glycosyl Phosphate Mimics
Synthesis, bioconjugation and stability studies of [18F]ethenesulfonyl Fuoride
Do you have a specific question regarding the purification of synthesised organic molecules? We have specialists who will quickly and efficiently provide you with competent application support or a feasibility study specifically tailored to your needs. Get in contact with our team via application@buchi.com or participate in our advanced chromatography trainings and bring your sample, that we can find the right solution for your specific separation problem. Register for training | 
